- Timely diagnosis, multidisciplinary care, and advanced limb-salvage treatment help young patient overcome Grade 3 Osteosarcoma
AHMEDABAD, GUJARAT | 09th JUNE 2026 | HCG Aastha Cancer Hospital successfully treated a complex case of Grade 3 Osteosarcoma, an aggressive form of bone cancer, in a 12-year-old girl from Rajasthan through a comprehensive multidisciplinary treatment approach involving chemotherapy, specialised limb-salvage surgery, and advanced supportive care.
The patient, Anaya Sharma, first began experiencing persistent swelling and severe pain in her left thigh and knee in August 2025. Initial investigations revealed the presence of a tumour in the femur bone. However, due to limited specialised oncology Facilities and the inability toobtain a definitive diagnosis, the family decided to seek expert treatment at HCG Aastha Cancer Hospital, Ahmedabad.
Under the care of Dr. Krisha Shah, Paediatric Haematologist and Oncologist, and Dr. Mayur Kamani, Orthopedic Onco-surgeon and Dr Kinjal Jani (Radiation Oncologist), the patient underwent further investigations and a biopsy, which confirmed the diagnosis of Grade 3 Osteosarcoma of the femur.
Following a detailed evaluation by the multidisciplinary tumour board, the HCG medical team formulated a personalised treatment plan consisting 4 cyclesof neoadjuvant chemotherapy, followed by tumour excision surgery and adjuvantchemotherapy.
Considering the prolonged duration of treatment, the patient was initially provided with a PICC (Peripherally Inserted Central Catheter) lineto avoid multiple IV-line puncturesduring chemotherapy administration. During the course of treatment, she developed complications related to the PICC line, which required its removal and further management through the frequent insertion of IV lines during subsequent chemotherapy cycles.
Through the first 4 cycles, the patient experienced multiple chemotherapy-related side effects including fever, nausea, vomiting, weakness, reduced appetite, and noticeable weight loss. Despite these physical and emotional challenges, she continued to show remarkable determination and resilience with constant support from her family and the medical team.
A major turning point in her treatment journey came after the completion of the fourth cycle of chemotherapy, when she underwent a highly specialised limb-salvage surgery. The procedure involved tumour resection combined with Extracorporeal Irradiation and Reimplantation Therapy (ECRT) by Dr Kinjal Jani, followed by plating, an advanced surgical approach aimed at preserving the affected limb while effectively treating the cancer.
The surgery was performed under the expertise of Dr. Mayur Kamani in collaboration with the Radiation Oncology team. The joint effort ensured precision-led treatment while maintaining the patient’s mobility and long-term quality of life. She also successfully completed remaining four cycles of chemotherapy in April 2026. A subsequent PET-CT scan conducted in May 2026 showed no evidence of active disease, and the patient is currently in remission.
Dr. Krisha Shah, Paediatric Haematologist and Oncologist, HCG Aastha Cancer Hospital, said: “Osteosarcoma is an aggressive bone cancer that commonly affects children and adolescents, making early diagnosis and timely treatment extremely important. In this case, despite multiple treatment-related challenges, the patientshowed exceptional courage throughout her journey. A coordinated multidisciplinary treatment approach helped us achieve positive clinical outcomes while also focusing on preserving her future mobility and quality of life.”
Speaking about the surgical intervention, Dr. Mayur Kamani, Orthopedic Onco-surgeon, HCG Aastha Cancer Hospital, said: “Treating bone cancer in growing children requires a highly balanced approach where the objective is not only cancer control, but also preservation of limb function and independence. Advanced limb-salvage procedures now allow us to treat such complex cases with greater precision while helping young patients continue their daily lives with confidence.”
The treatment journey was further supported through financial assistance provided by the HCG Foundation, which helped cover 90% portion of the medical expenses and ensured uninterrupted access to advanced cancer care. Even while undergoing intensive treatment, the patient continued her education through online classes and appeared for examinations whenever her health permitted. She is currently receiving physiotherapy and rehabilitation and is preparing to return to school in the coming months
Sharing her experience, Anaya Sharma, said: “When I first came to the hospital, I was scared and unsure about what would happen next. But the doctors, nurses, and staff at HCG constantly motivated me and supported me throughout my treatment journey. They gave me strength during my most difficult days and always made me feel hopeful. Today, I feel grateful that I can slowly return to my normal life again.”
Experts highlighted that regular follow-ups and long-term monitoring remain crucial after completion of treatment, especially during the first two years, as the risk of relapse is highest during this period. Continued rehabilitation, nutritional care, and monitoring for treatment-related side effects also play an important role in ensuring overall recovery and long-term well-being in paediatric cancer patients.
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